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KMID : 0359320150550010057
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Korean Journal of Veterinary Research
2015 Volume.55 No. 1 p.57 ~ p.60
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Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice
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Hue Jin-Joo
Lee Hu-Jang
Nam Sang-Yoon
Kim Jong-Soo
Lee Beom-Jun
Yun Young-Won
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Abstract
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To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 μCi/ mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
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KEYWORD
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accumulation, biodistribution, 177Lu, nanotoxicity, TCL-SPION
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